Search on: PROTEIN TYROSINE PHOSPHATASES 
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Descriptor English:   Protein Tyrosine Phosphatases 
Descriptor Spanish:   Proteínas-Tirosina Fosfatasas 
Descriptor Portuguese:   Proteínas Tirosina Fosfatases 
Synonyms English:   Phosphotyrosine Phosphatase
Protein-Tyrosine-Phosphatase
Tyrosyl Phosphoprotein Phosphatase  
Tree Number:   D08.811.277.352.650.775
Definition English:   An enzyme group that specifically dephosphorylates phosphotyrosyl residues in selected proteins. Together with PROTEIN-TYROSINE KINASE, it regulates tyrosine phosphorylation and dephosphorylation in cellular signal transduction and may play a role in cell growth control and carcinogenesis. 
Indexing Annotation English:   general; prefer specifics
History Note English:   2008(1985) 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
CT contraindications DF deficiency
DU diagnostic use DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects SE secretion
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   29866 
Unique Identifier:   D017027 

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